Everything about ceesdekker
Everything about ceesdekker
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Applying solitary-molecule optical and AFM imaging and power-spectroscopy techniques, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our study pursuits incorporate:
It absolutely was only within the nineteen nineties although, when nanotechnology experienced advanced to your level the place one molecules could possibly be manipulated, that the very first experimental products commenced to appear.
[Laughs] ‘It was certainly an excellent danger! At the time, I had been very well informed that it could go Erroneous Which I could turn into a lot less productive, but I just ignored that. Curiosity has always been my strongest driving drive. And by chance all of it worked out.’
2007, to start with genuine-time detection of strand Trade in homologous recombination by RecA; discovery of the low persistence size of finishes of microtubules; and fixed the mechanism of biosensing with carbon nanotubes
2015, discovery that condensin is a really versatile protein construction; and initial detection of DNA knots applying nanopores
Within the many years following these discoveries, my investigate pursuits shifted to biophysics and nanobiology, and I became less linked to the event of nanotube electronics. The focus of numerous scientists in the sector also shifted to graphene (exactly where, funnily enough, the main graphene ribbons ended up referred to as ‘nanotubes which are Slash open up alongside their length’) just after the discovery of The 2-dimensional content in 2004.
Because 2000 he moved to single-molecule biophysics and nanobiology, with investigate from DNA supercoiling scientific tests of nucleosomes and DNA repair service proteins to DNA translocation by way of nanopores. Not too long ago his study has centered on finding out cell division with microbes on chip, even though his final interest is during the route of recognizing artificial cells.
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‘You should not just take into consideration the queries of tomorrow, but in addition take into account the issues with the working day immediately after tomorrow’
Bulk-surface coupling identifies the mechanistic connection among Min-protein designs in vivo As well as in vitro
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Nanoscientist Cees Dekker is an amiable and flamboyant person who seems Considerably more youthful compared to 62 years he basically is – stylish glasses, psychedelic shirt, engaging smile – although not just one to waste time. He requires his time, but not more than vital.
One example is, we consider the nucleopore sophisticated, a gateway in between the mobile nucleus along with the cytoplasm. This is an extremely complicated procedure and for that reason tough to study inside of a mobile, so we use biomimetics. We reconstruct holes and after that insert individual things in the nucleopore complex to check transport as a result of it ceesdekker at The only-molecule amount.’
‘I'm driven by question and inquiries. On a fabric amount I obtain answers in physics, but I encounter my deepest joy with God. That faith also drives my science And just how I handle men and women.